Bal0n zei:
parcival zei:
Bal0n zei:
methylthioamphetamine, het zwavel broertje van pma
CH3SC6H4CH2CHNH2CH3
Heb jij dan voor mij misschien dit abstract:
M. Gobbi, M. Moia, L. Pirona, Miguel Reyes-Parada, Cecilia Scorza, and T. Mennini. P Methyl-thio-amphetamine and 1-(m-chlorophenyl)-piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. Journal of Neurochemistry 82: 1435-1443, (2002).
Laat je niet misleiden door het niet neurotoxische van MTA, dit product in in 1998 kort op de smartshop markt geweest en er zijn enkele doden gevallen. Ik heb het toen eens geproeft (voor ik wist van de overlijdens) en het kwam niet in de buurt van mdma, kwam traag op, en was niet echt stimulerend maar je bleef wel wakker. Het hart voelde niet echt ok.
op
http://www.trimbos.nl/default13535.html staat het ook vermeld .
J Neurochem. 2002 Sep;82(6):1435-43.
p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.
Gobbi M, Moia M, Pirona L, Ceglia I, Reyes-Parada M, Scorza C, Mennini T.
Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Italy.
The mechanism underlying the serotoninergic neurotoxicity of some amphetamine derivatives, such as p-chloroamphetamine (pCA) and 3,4-methylenedioxymethamphetamine (MDMA), is still debated. Their main acute effect, serotonin (5-HT) release from nerve endings, involves their interaction with 5-HT transporters (SERTs), as substrates. Although this interaction is required for the neurotoxic effects, 5-HT release alone may not be sufficient to induce long-term 5-HT deficits. Some non-neurotoxic compounds, including p-methylthioamphetamine (MTA) and 1-(m-chlorophenyl)piperazine (mCPP), have 5-HT releasing properties in vivo and in brain slices comparable to that of neurotoxic amphetamine derivatives. We measured 5-HT release in superfused rat brain synaptosomes preloaded with [3H]5-HT, a model that distinguishes a releasing effect from reuptake inhibition. MTA and mCPP induced much lower release than pCA and MDMA. The striking difference between our findings in synaptosomes and those obtained in vivo or in brain slices is probably related to a different compartmentalisation of 5-HT in the different experimental models. Studies in synaptosomes, where the vesicular storage of 5-HT is predominant, could therefore bring to light differences between neurotoxic and non-neurotoxic 5-HT releasing agents which cannot be appreciated in other experimental models and might be useful to identify the mechanisms responsible for the neurotoxicity induced by amphetamine derivatives.
Van het volgende artikel heb ik zelfs de volledige tekst (fotokopij) deze werkte mijn eerste interesse, maar het product is niet alleen teleurstellend maar ook nog eens gevaarlijk.
Huang X, Marona-Lewicka D, Nichols DE.
p-methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent.
Eur J Pharmacol. 1992 Dec 8;229(1):31-8.